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205809

IN VITRO ANTICANCER ACTIVITY OF NANAZOXID DRUG AGAINST ‎COLORECTAL CANCER CELL LINE AND ITS MOCLECULAR PATHWAYS

Article

Last updated: 28 Dec 2024

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Abstract

SUMMARY
                 Drug repurposing is gaining popularity in treatment discovery because it is a smart strategy to quickly exploit new molecular targets of a known clinically authorized drug in a variety of diseases, both existing and novel. Some early studies showed that hydroxychloroquine which has long been used for malaria, is used to reduce fever and inflammation of COVID-19 patients. Cancer is a major health issue worldwide. During the past years, some drugs are proved to be anticancer drugs as Raloxifene to treat breast cancer and Aspirin to treat colorectal cancer.
                 According to the national cancer institute the second most killer cancer is the cancer of colon and rectum around the world. Colorectal cancer is Egypt's seventh most prevalent cancer, accounting for 3.47 % cancers. Colon cancer patients (excluding rectal cancer) were expected to number somewhat more than 3,000.
Our aim in this project is to repurpose clinically used antibiotics in the Egyptian market for colorectal cancer.
Anticancer efficacy of numerous antibiotic drugs was being tested by screening them in monolayer (2D).Results showed that Nanazoxid as a promising drug as anti-cancer drug especially for colorectal cancer with IC50 (0.20 μg/ml) and was tested for its selectivity index on human cell line and was subjected to molecular analysis.
As a result, an antibiotic drug which is Nanazoxid proved that it could be repurposed as an anti-colorectal therapy with proper further research and development.

DOI

10.21608/eajast.2021.89088.1000

Keywords

colorectal cancer, Drug repurposing, antibiotics, human cell line, aspirin, COVID, 19, Nanazoxid

Authors

First Name

Nourhan

Last Name

Abed

MiddleName

-

Affiliation

Department of Biotechnology, Faculty of Science, Cairo University, Cairo, Egypt‎

Email

nourhan_muhammad@yahoo.com

City

Cairo

Orcid

-

First Name

Salwa

Last Name

El-hallouty

MiddleName

-

Affiliation

Drug Bioassay-Cell Culture Laboratory, Pharmacognosy Department, National Research Center, Dokki, Giza, ‎‎12622, Egypt‎

Email

-

City

-

Orcid

-

First Name

Emad

Last Name

El-Zayat

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Cairo University, Cairo, Egypt‎

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

El-Sherief

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt‎

Email

-

City

-

Orcid

-

Volume

1

Article Issue

2

Related Issue

28998

Issue Date

2021-11-01

Receive Date

2021-08-03

Publish Date

2021-11-01

Page Start

29

Page End

37

Print ISSN

2735-4628

Online ISSN

2786-0191

Article File

EAJAST_Volume 1_Issue 2_Pages 29-37.pdf

PDF . 932.1kB

Link

https://eajast.journals.ekb.eg/article_205809.html

Detail API

https://eajast.journals.ekb.eg/service?article_code=205809

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4

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Original articles

Type Code

1,893

Publication Type

Journal

Publication Title

Egyptian-Arab Journal of Applied Sciences and Technology

Publication Link

https://eajast.journals.ekb.eg/

MainTitle

IN VITRO ANTICANCER ACTIVITY OF NANAZOXID DRUG AGAINST ‎COLORECTAL CANCER CELL LINE AND ITS MOCLECULAR PATHWAYS

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Article

Created At

23 Jan 2023