The cardiovascular disease spectrum includes acute myocardial infarction, which enlarges the ongoing problem for the global health care delivery system. Many non-PCI medical facilities throughout the world continue to use pharmacoinvasive strategies as their first line of treatment. But it's still unclear when PCI should be performed following thrombolysis. We study when PCI should be performed following thrombolysis in this review. Conclusion: At this time, there isn't conclusive evidence about the best time to perform PCI following thrombolysis in a minimally invasive strategy, and more research is required to determine whether there is a material difference between early and late PCI after thrombolysis in terms of morbidity, mortality, and cost effectiveness. This will help standardize and improve the treatment protocol for post-thrombolysis PCI. The best time for PCI to be performed following thrombolytic therapy is not yet clear from the data, and further research is needed to establish the best time.