Viral hepatitis is a major global public health problem affecting hundreds of millions of people and is associated with significant morbidity and mortality. Hepatitis A is caused by infection with hepatitis A virus (HAV), a non-enveloped RNA virus that is classified as a picornavirus. This study has been conducted to determine the prevalence rate of anti-HAV among community in Sohag governorate, Egypt. Our result shows the age distribution, gender and education type of population in all villages (12) of Sohag governorate. The age distribution of the whole sample was mostly higher in age group above 50 years 34.3%, then 23% in age group from 20-30 years, then almost equally distributed in groups from 31-40 and 41-50 where they were 16.9%, and 17.1% respectively and finally the lowest in group less than 20 where it was 8.2%. The gender distributions of population in all villages, males were more prominent (74.9%) than females (25.1%). The study shows the Anti-HAV distribution of population in all villages, where only four participants were positive in Bailina, where the total prevalence of HAV was 0.4%. Four risk factors reflecting high mechanisms of HAV transmission have been associated with HAV infection including residing in rural areas, no education, blood transfusion and dental treatment. Exposures to surgery, history of schistosomiasis show no association with Anti-HAV. Among the community exposures, including blood donation but these associations are not important. We did not find abnormal levels of Biochemical analysis in HAV infected patients.