Nosocomial infections with Acinetobacter baumannii are increasing every day, making treatment with traditional antibiotics more complicated. This work aimed to investigate the antibacterial activity of Curcuma longa extracts against carbapenem-resistant isolates of A. baumannii. A  total of  90 samples (Sputum, n=40 and Urine, n=50) were collected and biochemically identified via Vitek -2 system. Ten isolates were identified as A. baumannii (10/90; 11.1%). (10/90; 100 %) of isolates identified were multi drug resistance (MDR). Curcuma longa  extracts aqueous and/or ethyl acetate of, exhibited a significant MBC value varying from 43.75 to 50.83 mg ml^-1 against A. baumannii isolates (A1, A2, A3, A5, A6, and A8), respectively. Within isolates A1 and A8, ethanol extracts revealed MBC with significant values (30 to 70 mg ml^-1) respectively. The main phytochemical compounds detected among 68 bioactive compounds in the extracts of ^C. ^longa over the GC- mass spectra analysis were Turmerone (59.42%), Beta-caryophyllene (16.66 %), Caryophyllene oxide (15.62 %), Isolongifol (12.14 %), Alpha-pinene (12.07 %), Citral (11.68 %), Curdione (11.0 %), B -Sesquiphellandrene (10.47% ), B-myrcene (8.12 %), D-Limonene (8.04 %). Bactericidal activity of C. longa against MDR A. baumannii were supported by phytochemical compounds that detected in GC-MS analysis.