Rodents are important in many ecosystems because they reproduce rapidly, and can function as food source for predators, mechanisms for seed dispersal and as diseases vectors. Rodents may act as reservoir hosts for important human parasitic diseases. The present study was focused on histopathological changes of rodent liver infected with a larval cestodes recorded at two locations situated at Sohag, Egypt. This study reported infection rate of 56% and 32% for rodents at the two locations, respectively. The study also showed that the incidence in females is higher than in males in the second location compared with that of the first location. Microscope examinations of the liver tissue sections revealed a wall cyst of larval cestode, Cysticercus fasciolaris in parenchyma consists of two compressed layers of highly proliferative fibrous connective tissue and inflammatory cells mainly lymphocytes. Inflammatory reaction was seen in the hepatic parenchyma around the cyst. Also, there are dilatation and congestion in the central and portal veins and infiltration of the liver parenchyma with inflammatory cells. The hepatocytes in the central and portal areas showed fatty degenerative changes. While, in the portal area the histological tissue of the liver showed microvesicular steatosis and edematous infiltration. Signs of inflammation including sinusoid widening and prominent kupffer cells were noted.