Samples form lungs; trachea and air sacs were collected from 40 turkey poults suffering from respiratory signs for bacteriological examination for isolation and identification mycoplasma spp. The results reaveld, 18 (45%) samples were +ve for mycoplasma spp. Antibiogram study of isolates revealed that pefloxacin and tiamulin was effective against mycoplasma. A total of 40, one day-old poults provide free from mycoplasma infection were divided into 4 equal groups. 1st group healthy (-ve control) 2nd, 3rd& 4th groups were artificially infected with Mycoplasma gallisepticum (MG), 2nd group infected non treated (+ve control), 3rd group infected treated with 5 mg pefloxacin / kg bwt in drinking water for 5 successive days and 4th groups was infected treated with 25mg tiamulin/kg bwt in drinking water for 5 successive days, At 1st and 10th days post treatment 5 poults from each group were sacrificed for record lesion scores % and two blood samples were taken from each poults for hematobiochemical parameters study.
Poults infected with Mycoplasma gallisepticum revealed loss of appetite, depression, sneezing, conjunctivitis, frothy exudation in eyes, air sacculitis 7 (70%), pericard-itis 7 (70%), perihepatitis 8 (80%) & mortality rate 4 (40(% beside induces significant incr-ease in WBCs, AST ALT, ALP uric acid, creatinine and significant decrease in weight gain. Phagocytic %, index, killing % IgA, IgG, IgM, T protein, albumin and globulin
It could be concluded that pefloxacin and tiamulin was effective in treatment Mycoplasma gallisepticum in poults and ameliorate severity of its lesions besides improving adverse effect in hematobiochemical parameters