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193211

COMPARATIVE SYUDY ON THE EFFECT OF SINGLE AND REPEATED DOSES OF THIACPHENICOL AND CHLORAMPHENICOL IN RATS

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Last updated: 05 Jan 2025

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Abstract

Thiamphenicol and chloramphenicol are known as two related drugs. However, it was claimed that the latter is more toxic. Evaluation of the effect of single and repeated doses on liver. Spleen, bone marrow in addition to mus cles at the site of injection was adopted. In addition, blood picture, serum glutamic oxal acetic transaminase (SGOT) and serum glutamic pyruvic transaminase ( SGPT ) were performed. Histopathological examination revealed that liver is the most affected organ with single and rep < /strong>eated doses of both drugs accomp < /strong>anied by increased level of SGOT and SGPT.Both drugs have the same drastic effect on liver and ser um enzymes together with hemopoeitic organs. The difference lies only in the extent of cha nge induced by single or more particular, repeated doses of either drugs.

DOI

10.21608/avmj.1977.193211

Authors

First Name

I.M.

Last Name

SHEHATA

MiddleName

-

Affiliation

Pathology and Parasitology Department. Faculty of Veterinary Medicine, University Cairo.

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Orcid

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First Name

R.E.M.

Last Name

DOGHAIM

MiddleName

-

Affiliation

Pathology and Parasitology Department. Faculty of Veterinary Medicine, University Cairo.

Email

-

City

-

Orcid

-

First Name

F.I.

Last Name

FARKOUH

MiddleName

-

Affiliation

Pathology and Parasitology Department. Faculty of Veterinary Medicine, University Cairo.

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Orcid

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Volume

4.2

Article Issue

8

Related Issue

27218

Issue Date

1977-05-01

Receive Date

1977-03-24

Publish Date

1977-05-01

Page Start

65

Page End

78

Print ISSN

1012-5973

Online ISSN

2314-5226

Article File

AVMJ_Volume 4.2_Issue 8_Pages 65-78.pdf

PDF . 6.2MB

Link

https://avmj.journals.ekb.eg/article_193211.html

Detail API

https://avmj.journals.ekb.eg/service?article_code=193211

Order

7

Type

Research article

Type Code

1,840

Publication Type

Journal

Publication Title

Assiut Veterinary Medical Journal

Publication Link

https://avmj.journals.ekb.eg/

MainTitle

COMPARATIVE SYUDY ON THE EFFECT OF SINGLE AND REPEATED DOSES OF THIACPHENICOL AND CHLORAMPHENICOL IN RATS

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Article

Created At

23 Jan 2023