Experimental closure of both ureters were conducted on five male dogs. Clinical, hae matological and biochemical changes were recorded before and at regular intervals following the operation till death. It was noticed that body temperature and respira tory rates lowered while the pulse rate accelerated postoperative. Haemoglobin con tent, packed cell volume and total leucocytic count were decreased till time of death. Serum urea, creatinine, inorganic phosphorus, potassium and sodiun were progressively increased post operation.