Clinical examination of 3822 sheep revealed enlargement of lymph nodes in 167 heads
(4.3%), higher percentage of infection in parotid gland (49.4%). Coryne ovis was isolated from one enlarged parotid lymph node of one sheep out of 13 slaughtered ones. Experimental infection by subcutaneous and intradermal inoculation revealed isolatiin of C.ovis from site of inoculation only, it was not isolated in case of scarification method. Interanasal infection resulted in Isolation of C.ovis from lungs of one animal only while in case of oral infection, C.ovis was isolated from the me sentric lymph nodes. Intravenous infection resulted in abscess formation in spleen, liver and bronchial lymph nodes.