Intravenous injection of a combined mixture of Vetalar-Rompun was performed in sheep. The desired anaesthetic effect was obtained by using small doses of the drugs. The average anaesthetic period persisted for 75 minutes. Clinical study revealed an increase in respiratory rate, as well as decrease in pulse rate and body temperature. Study of the haemogram before, during and after anaesthetization revealed decreased level of total red cell count, haemoglobin content, packed cell volume and total white cell count. Lymphopenia, eosinopenia with subsequent rise in neutrophils were obser ved. The activity of the enzymes GOT, GPT and alkaline phosp < strong>hatase was increased. The blood urea nitrogen showed marked elevation. The total serum protein, calcium and Inorganic phosphorous showed slight change. The studied blood parameters returned to their pre-anaesthetic values 48 hours after anaesthetization.