Five calves, I to it years old, were intradermally inoculated with a lovally isolated strain of C.pseudotuberculosis. Skin biopsies were taken 4, 8 & 12 hours of infection. The animals slaughtered after 1, 2, 4, 7 and 15 days. Grossly, inflammation and slight oedema of the skin at the sits of injection, congestion and necrotic changes in regio nal lymph nodes, toxic hepatitis and nephrosis. Microscopically, the most pronounced changes in the skin consisted of suppurative inflammation. This was accompanied with destruction and thrombosis of blood and lymph vessels The regional lymph nodes showed destruction and fragmentation of lymphoreticular elements and infiltrating leuocytes. In parenchymatous organs changes were mainly degenerative. Using Immunofluorescence, it has been demonstrated that the organism when intradermally injected it spreads from the site of inoculation only to regional lymph nodes.