Lantana camara fresh and dried leaves, and lantana processed extract when administered to rabbits it produced early liver damage manifest ed by icterus and intensive hydropic degeneration of the hepatic cells. This was accompanied by desquamative and necrotic changes in the bile duct epithelium and inflammatory changes in their wall. A proliferative reaction of the epithelial cells lining the bile ducts was also observed. In late stages, biliary cirrhosis developed with intensive proliferation of bile duct epithelium and formation of newly formed ductules.
In the kidneys, the early lesions were mainly tubular nephrosis together with an inflammatory interstitial reaction. In late stages, the condit ion developed nephrosclerosis.
In the lung, interstitial proliferation of the mesenchymal elements was the main change observed in the late stages,