Acute pancereatitis and diabetes were experimentally induced in cattle and buffaloes to study the effect of the diseases on glucose tolerance. The (K) value (glucose disappear ance coefficient, measured in percentage,' decrease of glucose/min) was calculated from the higher dose intravenous glucose tolerance test. Fifteen animals were allotted to three groups of five animats each as follows: Group 1: control, Group: Il pancreatitis affected animals, Group: III diabetic animals. The results indicated that: 1. High dose intravenous glucose-tolerance test was an effective tool for determining
glucose-tolerance in cattle and buffaloes. 2. Glucose tolerance of group Ill was markedly decreased compared with that of group < /p>
I & II. To determine if a simplified (K) value (calculated using 2 or 3 blood samples) could approximate the (K) value (calculated using 8 blood samples) simplified (K) values were derived from 5 and 120 minute blood sample values. These values closely approximated the standard (K) values, indicating the simplified value may be used in the clinical situation. The standard (K) value, however, is preferred for investiga tive work.