The present study was designed to investigate the effect of experimental hypothyroidism
induced by subcutaneous injection of rnethylthiouracil (M T U) on the morphological and
morphometrical changes in the kidneys of rats. Fifty rats were used in this experiment.
They were divided into Ii groups A,B,C and D which were treated by S/C. injection of
(M U T) at dose level l0, 0,5 0,2 0,l mg. per Kg body weight respectively. ln addition,
fifth group E of 10 animals was used as control.
The morphometrical changes revealed that.
l- The gromerular tuft is significantly decreased by administration of antithyroid drug.
2- lncrease in the muclear diameter in the first two groups.
3~ increase in the glomerular diameter in the first group.