A total of 30 native breed cows were used in this investigation. Ten animals were clinically healthy, which served as a control, while the diseased cows were selected according to rectal findings. The animals were clinically and rectally examined. No obvious clinical symptoms were achieved, while hard irregular masses in the pelvic cavity were palpated. Biochemical analysis includes serum total protei ns, cholesterol, total lipids, glucose, S-GOT, S-GPT -GT, thyroid uptake and thyroxin were carried out in both healthy and diseased Cows. Hypercholesterolaemia and hyperlipaemia were associated with hypothyroidism in diseased cattle.