The skin speciemens were taken from nasolabial region of 20 healthy mature Egyptian buffaloes. The speciemens were fixed, sectioned and stained with the different histological and histochemical methods. The nasolabial glands of buffaloes are compound tubuloacinar merocrine sweat glands distributed within the nasolabial region. Dark and clear cells were demonstrated in the secretory end-pieces, as well as cent roacinar cells were observed between the glandular cells and the lumen of the secretory end-pieces.