Eight sheep were included in this investigation and divided into two groups. Group (1) composed of four animals and operated with unilateral parotid duct section. Group (II) also composed of four animals and operated with section of parotid ducts bilaterally. Blood and serum samples were collected for blood gasses and electrolytes assay. Preoperative mean values of group (1) for blood pH, Pc02, PO2 HCO3, TCO2 and Base excess were 7.372, 46.07 mmHg, 43.85 mmHg, 27.77 mm01/L, 29.15 mmol/L and 2.8 mmol/L respectively, while the preoperative values for group (II) were 7.452, 45.55 mmHg, 41.87 mmHg, 28.9 mmol/ L, 30.4 mmol/L and 3.2 mmol/L respectively. A marked alteration in Acid-Base values and electrolytes of group (11) were opserved after the first day of operation, and all animals of this group were died. Slight changes were observed on group (1) one day post-operation and the animals retained their normal values at the third post-operation.