One hundred rats and mice of different species (14 Rattus rattus ratus, 31 Rattus norvegicus, 16 Rattus alexandrinus, 13 arvican thus neloticus, 5 Acomys cahirinus and 21 Mus musculus) were trapped from different localities at Edfina village and examined for the presence of Salmonella organisms. S.typhimurium, S.dublin, S.enteritidis, S.paratyphi A, S.paratyphi B and S.newport were isolated at a rate of 6,4,4,2,2 and 2% respectively. The public health important of each strain for both animals and human beings was discussed.