Doses of 100 ug up to 15 mg ivermectine/kg b.w. were given to groups of chicken and prooved to be non toxic and caused no abnor mal signs of mortality. The pharmacological evaluation revealed a non significant changes in the physiological functions of different systems in rats and mice. Doses of 200, 400X800 ug/kg b.w. had no effect on egg production, the quality of eggs remained unchanged externally and internally. The drug had no deleterious effect on fertili ty and hatchability rates.