The effect of long-term treatment with various doses of TP or hCG on the prepuce and preputial glands was studied on 33 male rabbits of pure Bouscat breed. The preputial epidermis, sebaceous and tubular glands exhibited a significant dose- related increase in activity in rabbits treated with various doses of testesterone propionate (TP) other than those treated with human chorionic gonadotropins (hCG). In the preputial epidermis, the stratum cornium was greatly increased in thickness, while the stratum basale showed aggravated mitotic activity. Also the sebaceous glands were enlarged and activated. Moreover, the tubular glands presented a significant increment in the diameter of their secretory end epieces as well as in the hight of the glandular epithelium.