The clinical, haematological and some biochemical studies were con ducted on seventy-four buffaloe calves during the prevalence of outbreaks accampanied with respiratory and alimentary manifistations. Respiratory acidosis was observed in the group of calves showing symptoms of bronchopneumonia. Metabolic acidosis was recorded in calves suffering from enteritis. However mixed acidosis (respiratory and metabolic) was noticed in the group of calves with pnumoenteri tis. Leukopenia was reported at the early stage of illness, however leukocytosis was observed later on associated with lowered values of total red cell count and Hb concentration in most of diseased cases. Serological examinations revealed the presence of antibodies against IBR and MD/VD viruses in the most of diseased cases.