This study was carried out on 35 native breed Osimi sheep, Ten animals were aparantly healthy and kept as control. Twenty Five sheep were disease and showed a signs of liver illness in the form of depression aneroxia, diarrhea or constipa tion and in late stage recumbency and death. The mean values for serum total protein, Albumen,
Band -globulin in healthy sheep were 74.55 g/155.63%, 9.61%, 9.58% and 18.58% respectively while in diseased sheep the values were 50.47 g/1, 37.81%, 15.02% 23.34%, 23.82% and 23.82 respectively.