Fish has become a highly productive industry in Egypt due to the pressure of a rapidly expanding human population. Neverthless, a number of parasites with larval stages in fresh water Nile fish have a piscivorous mammalian carnivore as their normal final host and are able to infect man because of low host specificity of the adult stage. The present study attempts to find out any metacercarial indout any metacercarial infection in tissues of organs of Schilbe mystis collected from markets in Sohag province. The study showed that 70% of the infection was in subcutaneous tissue, muscles and base of fins, while liver, kidney, spleen, roos, gills, intestinal mucosa lining of body cavity and brain with its tissues surrounding it are free of the infection. The metacercarial isolation having 53.85 cysts per gram of fish meat that classified them into two types related to two families, Heterophyidae and Cyathocotylidae.