A total of 30 native breed cows in Assiut Egypt were used in this investigation. Ten cows were clinically healthy which served as a control. The diseased cows were selected according to the rectal findings. All animals were examined clinically. The clinical signs in some cases in the form of mild constipation or diarrhae, mild tympany, difficulties at dilivery or abortion, while in some other cases no clinical signs were achived. Rectal examination of diseased cows revealed a hard irrigular masses, varied in shape and size in the pelvic cavity, around the intesti ne, kidneys and omentum. Serum protein electrophoresis was carried out using Agrose-film (Corning Acl Uni. Film). Serum electrophoresis revealed a marked decrease in serum Albumen, and significant rise in gamma-globulin value. No changes were observed in the values of alpha B-globulin and total protein as well.