Experimental ligation of the major pancreatic duct was conduct ed on 9 dogs. Blood and faecal samples were collected from the examined dogs before and at 3,7,15,21 and 28 days after ligation.
Haematological studies revealed a significant elevation in total erythrocytic count and packed cell volume. A moderate elevat ion in total leucocytic count associated with slight lymphocytosis and neutropenia have been recorded however normal count again was observed lateron.
Biochemical analysis revealed a highly significant elevation (P/_0.01) in the levels of blood serum glucose, cholesterol, total lipids post operation which returned to the normal at 28 days post-ligation. Blood serum amylase showed a highly significant increase that extended all over the experimental period. A highly significant decrease in blood serum electrolytes was evident. Faecal trypsin was varied from moderate to highly postive degree in the examined dogs.