Nine sheep of both sexes were used in this investigation. The animals were classified into 3 groups (each of 3 animals). Doses of Rompun injection were 0.3, 0.6, 1.0 mg/kg body weight respectively. Tempe rature, pulse and respiration rates before and after Rompun injection were recorded. Clinical signs were also demonstrated. The animals of all groups showed a different degree of alkalosis. Severe alkalosis was noticed in animals given Rompun in a dose of 0.6 mg/kg body weight, while rapid appearance of alkalosis in animals received Rompun in dose of 1.0 mg/kg body weight. Animals in group 3 in addition showed good analgesia and anaesthesa without any symptoms of toxication.