The effect of post-milking disinfectants (lodophor at concentration of 5000 mg available lodine/liter and Quaternary ammonium compound (Q.A.C.) at concentration of 1:320 as a prophylactive measure in control of mastitis was studied. Our investigation proved that the bactericidal efficacy of lodophor aganist Strepcocci. Staph. aureus and Coliforms was better than Q.A.C. On the basis of bacteriological data the reduction in infected quarters by lodophor was 42.5% while for Q.A.C. was 22.5%. Finally results concluded that mastitis control system must be including the teat dipping especially with lo dophor which lead to economical benefit.