In the present investigation, a certain, anatomical studies on the tendon sheaths of the extensor muscles of the manus in the donkey were performed; including the beginning, termination, position, relation, and measurements of each tendon sheath. From the clinical point of view, the more accessible site for injection of each synovial sheath was determined, which is important in the diagnostic and therapeutic purposes. In general, the anatomical features of the tendon sheaths in donkey resemble those found in horse, however, the dissimilarity was also reported.