Thirty-five sheep were included in this study, 10 animals were healthy and kept as control, while 25 animals were diseased and showed the signs of necrotic liver disease. Bacteriologically the caustive microorganism cl. novyi was isolated and the toxins were identified, fasciola eggs were detected in the faeces of diseased sheep. A marked drop in values of serum total protein, and marked increase in values of both serum GOT and GPT enzymes. Micromorphological examination indicated hepatic cell degeneration and focal necrosis, congestion and odema. The organism arranged single or in pairs could be also detected.