In this work, the clinical signs and some biochemical alterations of unthrifty sheep suffering from hypocuprosis as will as clinically healthy one were recorded. The diseased sheep were hypocupra emic in comparison with control group. The mean values of blood serum copper and caeruloplasmin of diseased sheep were 130.85+8.42 mg% and 80.75+0.58 U/L., respectively.
Strong positive correlation (r=0.973) was obtained between blood serum copper level and caeruloplasmin activity, indicating the usefullness of the activity of this enzyme as an alternative assay for copper deficiency.