Hormonal sensitization of the spayed mice followed by unilateral induction of decidual cell reaction (DCR) in the endometrium resulted in significant increases in both uterine weights and in permeability of the blood-uterine (B-U) barrier of decidualized horns over those with no decidual reaction (P/ 0.001) and (P/ 0.01) respectively. These changes were significantly reduced following indomethacin treatment (1 mg/100 g b.w. injected S./C. at 5:00, 10:00 and 15:00 on the 4th Day following the application of the decidual stimulus).
The results of the present study showed that the B-U barrier is still functioning following the induction of the DCR in mice uteri. Besides, the importance of prostaglandin synthesis in increa sing the permeability of the B-U barrier during the DCR process was demonstrated.