Two sporadic outbreaks of arthritis in 2 groups of buffalo calves arose from infection by Corynebacterium spp. The joints most commonly involved were the hocks, stifles and knees, and uncom monly were the fet lock and the synovial sheath of flexor tendon. The animals showed prominent clinical signs. Joints were enlarged. Arthritis greatly impeded locomotion. From the lesions Coryn. spp (Coryn. ovis in majority of cases and Coryn pyogenes in few instances) were recovered in pure culture. Histopathological changes were observed in joint capsules, lymph glands, liver and kidneys. Recovery occurred with treatment. The source of the infection and route of entry of the organisms to the body is a matter of conjecture. No trial was taken to produce the disease experi mentally in this study.