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189357

THE INFLUENCES OF METHYL PREDNISOLONE ON PUBERTY AND ESTROUS CYCLE OF FEMALE ALBINO RATS

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Last updated: 28 Dec 2024

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Abstract

The present study showed that injection of 1.0 or 2.0 mg methyl prednisolone acetate (MPA) into immature female rats resulted in a significant decrease in their rate of growth, increased deaths and retardation of the onset of p < /strong>uberty. Injection of MPA into immature female rats resulted in a significant decrease in serum FSH and increase LH level without affecting their concentration in the pituitaries.
Administration of MPA into est rous rats resulted in a significant increase of FSH concentration in the serum and pituitary. MPA injection increased serum LH level, with a pronounced decrease of its concentration in the pituitary.
During diestrus, administration of MPA led to a pronounced decrease in serum FSH level accompanied with a rise of its concentration in the pituitaries. Pituitary LH contents decreased without influencing serum LH level.
It seems that, Exces methyl prednisolone acetate have an adverse effect on gonadal function which is attributed to its catabolic nature,

DOI

10.21608/avmj.1988.189357

Authors

First Name

WAFAA F.

Last Name

ALI

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First Name

NAHED

Last Name

EL-TOUKHY

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First Name

A.

Last Name

ABOUL-ELA

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First Name

F.A.

Last Name

SOLIMAN

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Volume

20.2

Article Issue

40

Related Issue

27071

Issue Date

1988-09-01

Receive Date

1988-02-02

Publish Date

1988-09-01

Page Start

1

Page End

6

Print ISSN

1012-5973

Online ISSN

2314-5226

Article File

AVMJ_Volume 20.2_Issue 40_Pages 1-6.pdf

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https://avmj.journals.ekb.eg/article_189357.html

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https://avmj.journals.ekb.eg/service?article_code=189357

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Research article

Type Code

1,840

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Journal

Publication Title

Assiut Veterinary Medical Journal

Publication Link

https://avmj.journals.ekb.eg/

MainTitle

THE INFLUENCES OF METHYL PREDNISOLONE ON PUBERTY AND ESTROUS CYCLE OF FEMALE ALBINO RATS

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Article

Created At

23 Jan 2023