Two outbreaks of inclusion body hepatitis (BH) were observed in broiler poultry farms at Assiut and El-Kalubia governorates. Morbidity rate was about 60%, while the commulative mortalities reached 12% during a course of two weeks. The post-mortem findings, and the hepatic histomorphological and cytopathological alterations were described and illustrated. The causative virus was serologically identified. Moreover, the disease was successfully reproduced in susceptible chickens. Serologic al survey in the neighbouring farms revealed the wide spread of adeno virus infection.