Nine sheep of both sexes were used in this study. The animals were divided into three groups. The first group received xylazine only in a dose rate of 1.0 mg/kg B.Wt. intramuscularly, the second group injected intravenously nikethamide in a dose of 40 mg/kg B.W.t 50 minutes after intramuscular administration of xylazine, while the third group received caffiene 20 mg/kg B.Wt. in intravenously 50 minutes after intramuscular xylazine injection. Time and state of sedation, recumbendy, muscles condit ion, salivation and urination were noticed and recorded. Clinical examinat ion including body temperature, pulse and respiratory rate before and during experiment were recorded. Blood gases and acid-base balance were also demonestrated. Nikethamide and caffiene gave a stimulant effect for sheep sedated with xylazine.