Out of 100 collected samples of Tilapia species, twenty fish (15 T.nilotica and 5 T.galilaea) were infected with Saprolegniasis. The most common clinical signs of thedisease were cotton-like growth on the head region, operculum, fins, body surface and eyes. In addition, some ulcerations were observed on the head region of some infected fish. saprolegina parasitica coker was recovered from theskin lesions, fins and gills of infected fish. Experimentaly, theinfection with Saprolegnia parasitica coker in Tilapia nilotica and T.galilaea was transmitted by intramuscular injection and by application of the fungal isolate on abraded skin. T.nilotica was themore susceptible to the disease than T.galilaea.