The effect of hypervitaminosis D on the kidney of the albino rats has been studied. The following results have demonstrated:
A) Histological changes:
In the postnatal changes: Some convoluted tubules and collecting tubules show degeneration and the others are swollen with pyknotic nuclei. The brush borders of some proximal convoluted tubules are disappeared. The amount of collagenous fibers is markedly increased. Calcium depos its were observed in the glomeruler tufts, cells of convoluted and collec ting tubules, loops of Henle and blood vessels.
In the adult stages: Hypervitaminosis causes other histological changes in the kidney of rats. Some cells of the convoluted tubules and cellecting tubules showed necrosis. Extravasated red blood corpuscles are observed and cluster of rusty brown particles are occasionally encountered in the blood vessels.
B) Histochemical changes:
The carbohydrate substances are increased in the postnatal rats of 21-and 28-days old and adult stages. The proteinic content is slightly elevated specially in adult stages.