Haematological picture and biochemical analysis of blood serum of naturally infected adult New Zealand rabbits with Listeria monocytogenes and healthy ones were performed. The study was designed to evaluate the role of the above mentioned examinations in the diagnosis of listeriosis in rabbits. Anaemia and leucocytosis were observed in diseased group. Hypoalbumi naemia and slight elevation of serum globulin level were evident in infected rabbits than healthy one. There were no significant differences in the changes between the two groups in case of blood serum 'glucose, creatinine and urea nitrogen. A severe drop in serum electrolytes was found in disea sed group when compaired with healthy ones. Our results indicated that haematological picture and biochemical analysis of blood serum could be of value if it is used together with other laboratory tests for diagnosis of listeriosis.