Rompun in comparison with Lidocaine for lumbosacral epidural analgesia was evaluated in 6 rabbits. To role out the possibility that the epidural Rompun acted by systemic absorption, the intramuscular effects of the drug were also tested.
[pidural administration of Rompun (7mg/kg B wt) induced epidural analgesia nearly equivelent to Lidocaine, 2% solution (0.5 ml/ 20 cm from the animal length). While the epidural injection of Rompum caused some behavioral changes, the intramuscular administration had no epidural effects. The Epidurally injected drug induced a pronounced hind limbs muscle relaxation. Both Rompun and Lidocaine may be considered safe and efficacious lumbosacral epidural analgesics for rabbits.