A total of 36 of susceptible sheep used to detect the immune response of alum gel Rift vally fever vaccine (RVF) and the lyophilized skimed milk RVF vaccine which was selected from other lyophilized ones (gelatin RVF vaccine and sucrose-lact. albumin RVF vaccine) according to their potency test (EDC) in swiss-mice. The immune response was measured by serum neutralization test (SNT), commplement fixation test (CET) and the agar gel precipitation (AGP) test. The alum gel RVF vaccine and the lyophilized skimed milk vaccine produced a high immunogenic response and good protection from infection with RVF virus in sheep.