Acute experimental laminitis was induced in horses by feeding carbohydrate ration. therapy of acute laminitis started within 8 hours from the beginning of the signs. The different criteria of clinical improvement were recorded. It was found that DMSO (70-90%) was effective and potent as anti-in flammatory and vasodilator than phenylbutazone therapy. In addition, the results showed that after clinical improvement, the animals showed degrees of pedal rotation and histopathological changes within the hoof tissues. Laminitis therapy had potent effects on restortion of the disturbed circulation within the hoof, and at the same time it minimized epidermal destruction.