An outbreak of enzootic bronchopneumonia with high morbidity and mortality rates was recorded in fattening buffalo calves. The major clinical manifestations were dyspnoea, mucopurulent nasal discharges, coughing and abnormal respiratory sounds with elevated body tempera ture. Chronic necrotizing suppurative pneumonia, gangerenous pneumonia as well as metastatic abscesses were recorded in pathological examina tion of pulmonary tissue. Such changes were closely related to the
period of illness. Subacute and/or chronic interstitial nephritis was evidenced pathologically in some affected animals. Corynebacterium pyogenes, Haemalytic E.coli and Mycoplasma Sp. were isolated from nasal swabs & pulmonary tissues. Microcytic hypochromic anaemia was revealed in diseased animals. Lecucytosis was evidenced in some affect ed animals while leucopenia was noticed in some other affected calves. Hyperglycaemia and hyperglobulinaemia were noticed in diseased animals. Preventive and therapeutic measures stopped the progression of the disease among the clinically healthy heardmates, while in advanced cases recovery was difficult and all chronic advanced cases were completely destructed.