Organs and blood from Tilabia nilotica fish suspected to be intoxicated with fluorine and sulphur were studied clinically and pathologically. Differential Leucocytic count revealed moderate degree of Lymphopenia and neutrophilia. Pathological changes were observed in some parenchy matous organs including toxic hepatitis, Ulcerative and necrotic gastritis, tubular nephrosis, degenerative myocarditis and bronchitis. Degenerative and destructive lesions were also observed in the spleen. In conclusion the study evaluated the hazardous effect of industrial intoxication on Tilabia nilotica by fluorine and sulphur emitting from factory of fertilizer. Moreover it has been established that fluorosis and sulphurosis constitutes a serious hazardous to the health of Tilabia nilotica fish as it causes destruction of immune system with a subsequent lowering of the resis tance of the affected fish. Further more lesions observed in the paren chymatous organs of the intoxicated fish was too sever to kill it.