Thirty-eight balady ewes (2-3 years age) were included in this investigation to study the clinical signs of ovine cryptococcosis; isolation and identification of the causative agent Cryptococcus neoformans beside trials to evaluate Crypto-LA test as an aid and rapid method for diagnosis of the disease in ewes. Crypto-LA test proved 100% similarity to both the clinical signs of the disease and isolation of its causative fungus. The test was positive for the disease at 1/8 titre or 1+ on slide agglutination test.