The present investigation was a trial to control the terrestial snail "Pleurodonte orbiculata" which have a high economic and medical importance in the Egyptian semi-arid area (away from the Nile Valley). The experiment was done by using various types of chemicals used normally in the field including molluscicides (as Baylauscide & Copper sulphate), animals insecticides (as Diazenon) and plant insecticides (as Dimethoate 40% & Dupont Lanate 20%). The results showed that the plant insecticides were the most safe and efficient in controlling these snails even when used in its natural dose used in the field. The ideal methods for exposure of strong land snails to the chemicals and its efficacy were discussed.