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186641

THE EFFECT OF AD, E VITAMIN MIXTURE ON EXPERIMENTALLY INDUCED MEPHOSFOLAN SHORT TERM TOXICITY IN MIC

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Last updated: 28 Dec 2024

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Abstract

In this study, sixty mice were used for induction of short term toxicity with organophosp < /strong>horus comp < /strong>ound 'mephosfolan". They received tenth of the LD so twice weekly for two months. Twenty mice were then treated with AD, E vitamin mixture for further one month. Samples for histopathological and hematological investigations were taken. Histopathological changes after two months toxicity with mep < /strong>hosfolan were mainly degenerative and vascular. They were prominent in the liver, kidney, testis, lung heart, and intestine. Hematological examination revealed a significant decrease in total erythrocytic count, total leukocytic count, hemoglobin concentration, and packed cell volume. A highly significant decrease in true choline estrase activity was observed. Treatmemt with AD, E vitamin mixture for one month resulted only in regeneration of the testis. The other organs as well as the hematological p < /strong>arameters did not resp < /strong>ond. Sp < /strong>ontaneous recpvery was observed in the true chroline estrase activiity without significant differences between vitamin mixture treated and non-treated groups. The significance of these results was discussed.

DOI

10.21608/avmj.1992.186641

Authors

First Name

H.A.

Last Name

SALEM

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Orcid

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First Name

S.S.

Last Name

EL-BALLAL

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First Name

A.Sh.

Last Name

SEDDEK

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-

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Volume

28.1

Article Issue

55

Related Issue

26915

Issue Date

1992-10-01

Receive Date

1992-09-28

Publish Date

1992-10-01

Page Start

158

Page End

173

Print ISSN

1012-5973

Online ISSN

2314-5226

Article File

AVMJ_Volume 28.1_Issue 55_Pages 158-173.pdf

PDF . 6.5MB

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https://avmj.journals.ekb.eg/article_186641.html

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https://avmj.journals.ekb.eg/service?article_code=186641

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14

Type

Research article

Type Code

1,840

Publication Type

Journal

Publication Title

Assiut Veterinary Medical Journal

Publication Link

https://avmj.journals.ekb.eg/

MainTitle

THE EFFECT OF AD, E VITAMIN MIXTURE ON EXPERIMENTALLY INDUCED MEPHOSFOLAN SHORT TERM TOXICITY IN MIC

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Article

Created At

23 Jan 2023