SUMMEARY The present study was conducted to elucidate serum profile of some microelements (copper, zinc, selenium and manganese) in cyclic non-breeding (CNB) dairy cows. Thirty two Friesian and Crossbred dairy COWS were used (16 CNB COWS and 16 normal cyclic herdmates served as control). Blood samples were collected from all animals during follicular phase, serum was harvested and assayed for determination of copper, zinc, selenium and manganese. The results revealed significant (P < 0.05) lower serum levels of copper, zinc and manganese in CNB than control herdmates. Likewise serum selenium showed highly significant (P < 0.01) decrease in comparison to their contemporaries. It could be suggested that deficiency of copper, zinc, selenium and manganese might play a contributing vital factor incriminating in cyclic non-breeding dairy cows syndrome.