Eighty Fayoumi chickens of six weeks age were used in the present study. Chickens were kept on a basal ration containing selenium (0.15 pmm) and Vit. E (100 iu/Kg diet). They were allocated randomly into four groups 20 bird in each. They received selenium (Ten times the basal diet) and/or Vit. E (20 iu/Kg diet) for about five weeks. The amylolytic, tryptic and lipolytic activities in gut and sera contents were measured. Results obtained showed that, addition of selenium and/or Vit. E to the diet of broilers increased the enzymatic activities in the intestinal contents which may be of beneficial effect in protecting pancreatic and hepatic tissues from some effects. The data ensured that was proved before about the increase in growth of the chickens fed diets supplemented with selenium and/or Vit. E.