In this work the anatomical features of the median and ulnar nerves in donkey were studied in detail concerning the course, position, termination, colleteral branches as well as supplied muscles and skin. It can be concluded that the ulnar neurectomy in donkey has evident signs than the median neurectomy. It is important to take in consideration that the site of the proximal metacarpal nerve block differs in both sides, it is located in the lateral side higher than in the medial one.