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185379

EFFECT OF MELATONIN ON BODY TEMPERATURE IN THE RABBITS

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Last updated: 05 Jan 2025

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Abstract

Intravenous administration of melatonin at doses of M 10 587 0.1-1 mg\kg BW in mature male rabbits decreased the best rectal temperature. The maximum effect, about 0.90 *°C, was reached with the highest dose (1 mg/kg) at 15 min after injection of melatonin. In addition, melatonin antagonized the prostaglandin Fza. (PGF 20)-induced hyp < /strong>erthermia. The hypothermic effect of melatonin in hyperthermic rabbits was more marked than that in animals with normal body temperature. Atropine, hydergine and prop < /strong>ranolol did not antagonize the hypothermic effect of melatonin. It can be concluded that melatonin decreases the body temp < /strong>erature in normal rabbits as well as in rabbits with hyp < /strong>erthermia. These results suggest that the hypothermic effect of melatonin is not mediated through the cholinergic or adrenergic recep < /strong>tors and may be due to its direct relaxant effect on the wall of the blood vessels. Also, melatonin may act centrally through inhibition of
PG synthesis and release.

DOI

10.21608/avmj.1994.185379

Keywords

Melatonin, body temprature and rabbits

Authors

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EMTETHAL M.

Last Name

MOSTAFA

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First Name

IBTISAM M.

Last Name

ELMILIGYDD

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First Name

M.M.

Last Name

ANWAR

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Volume

31.1

Article Issue

61

Related Issue

26614

Issue Date

1994-04-01

Receive Date

1994-04-17

Publish Date

1994-04-01

Page Start

345

Page End

355

Print ISSN

1012-5973

Online ISSN

2314-5226

Article File

AVMJ_Volume 31.1_Issue 61_Pages 345-355.pdf

PDF . 4.5MB

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https://avmj.journals.ekb.eg/article_185379.html

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https://avmj.journals.ekb.eg/service?article_code=185379

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Research article

Type Code

1,840

Publication Type

Journal

Publication Title

Assiut Veterinary Medical Journal

Publication Link

https://avmj.journals.ekb.eg/

MainTitle

EFFECT OF MELATONIN ON BODY TEMPERATURE IN THE RABBITS

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Article

Created At

23 Jan 2023